Anti-KIF2C Antibody

KIF2C (Kinesin Family Member 2C), also known as MCAK, is a microtubule-depolymerizing kinesin-13 motor protein essential for accurate chromosome congression, metaphase plate alignment, and correction of erroneous kinetochore-microtubule attachments during mitosis. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against KIF2C and cross-reacts with human, mouse, and rat samples. The reagent is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, with a 100 µL total volume, and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows targeting cell-cycle, spindle-assembly, and centromere or kinetochore research. The polyclonal format increases the chance of recognizing multiple epitopes on KIF2C, which is helpful when probing both denatured lysates by Western blot and native structures in fixed cells by immunofluorescence. Investigators studying mitotic fidelity, aneuploidy, cancer cell division, or microtubule dynamics can use this reagent to confirm expression, track centromere localization during prometaphase and metaphase, and assess phenotypes following RNAi, CRISPR, or small-molecule inhibition of KIF2C and MCAK activity.