Anti-KIDINS220 Antibody

This rabbit polyclonal IgG antibody targets KIDINS220 (Kinase D-interacting substrate of 220 kDa), a multi-pass transmembrane scaffold protein originally identified as ARMS (Ankyrin Repeat-rich Membrane Spanning) and a downstream effector of neurotrophin and Trk-driven MAPK/ERK signaling. The unconjugated reagent from Antibodies.com is supplied as 200 µl of polyclonal antiserum in a vial, validated for Western blot detection of the human protein in cell and tissue lysates.

KIDINS220 couples Trk receptor activation to downstream pathways controlling neuronal differentiation, survival, and synaptic plasticity, and researchers use anti-KIDINS220 reagents to monitor full-length versus truncated isoforms in differentiating neurons, neuroblastoma lines, and models of activity-dependent signaling. The antibody is also applied in studies of T-cell receptor signaling, vesicular trafficking, and the spastic paraplegia / intellectual disability spectrum associated with KIDINS220 variants. Aliquot upon receipt and store at -20 °C, avoiding repeated freeze-thaw cycles to preserve reactivity with the human target.