Anti-KIAA0802 Antibody

This unconjugated rabbit polyclonal reagent targets KIAA0802 (also referenced as MTREX / MTR4 / SKIV2L2), a DExH-box RNA helicase that functions as a core subunit of the nuclear SKI complex, channeling substrate transcripts to the RNA exosome for 3'-to-5' processing and quality-control degradation. From Antibodies.com, the antibody is supplied as 100 µl of polyclonal antiserum raised in rabbit, with no fluorophore or enzyme conjugate attached, leaving it compatible with secondary-label workflows of the researcher's choosing. Common applications include western blot detection of endogenous MTREX in whole-cell and nuclear lysates, immunohistochemistry on fixed tissue sections, immunofluorescence localization to the nucleolus where the helicase concentrates, and immunoprecipitation of the native SKI complex from mammalian extracts. Store aliquots frozen at -20°C in single-use working volumes to limit freeze-thaw cycles, avoid extended exposure of the stock to room temperature, and protect from light where possible. Each lot is affinity-purified and supports standard immunodetection protocols across human, mouse, and rat samples, enabling studies of ribosome biogenesis, rRNA maturation, snoRNA processing, and nuclear RNA surveillance.