Anti-Keratin 17 Antibody

Produced in rabbit hosts, this polyclonal antibody from Antibodies.com targets Keratin 17 (KRT17), a type I intermediate filament protein expressed in basal epithelia, and is supplied as 100 µl of unconjugated antisera in a single vial format suitable for western blot, immunohistochemistry, and immunofluorescence workflows.

Validated reactivity spans human, mouse, and rat samples, enabling cross-species tissue surveys and comparative studies of epithelial biology in development, homeostasis, and disease.

Keratin 17 is normally restricted to basal keratinocytes of stratified epithelia, hair follicles, nail beds, and certain glandular structures, and it is rapidly upregulated during wound repair and in stress-responsive epithelial contexts. Researchers commonly apply this reagent to study basal cell differentiation programs, epithelial-mesenchymal transitions, and tumor pathology where KRT17 expression is associated with basal-like and squamous carcinoma phenotypes, as well as inflammatory skin disorders such as psoriasis.

Because the reagent is unconjugated, it can be paired with secondary antibodies of choice (HRP, fluorophore-labeled, or biotin conjugates) to match specific detection chemistries. Refrigerated storage with aliquoting to limit freeze-thaw cycles is recommended, preserving activity across extended experimental timelines in active research laboratories.