Anti-KEAP1 Antibody

Supplied as 100 µL of unconjugated rabbit polyclonal antiserum, this Antibodies.com reagent targets Kelch-like ECH-associated protein 1 (KEAP1) for Western blot and immunohistochemistry workflows on human, mouse, and rat samples. KEAP1 acts as the cytosolic repressor that directs NRF2 toward ubiquitination, so this reagent is useful for studies of redox homeostasis, xenobiotic metabolism, and NRF2 pathway activation in cancer, neurodegeneration, and inflammation models. Polyclonal reactivity broadens epitope coverage across the KEAP1 protein, which is helpful when examining post-translational modifications or alternative splice variants. Researchers commonly deploy the antibody to confirm KEAP1 expression in tissue sections via IHC and to detect endogenous protein levels by immunoblotting, supporting work on how KEAP1 mutations or dysregulation drive chemoresistance and tumor progression. Storage at 4 °C preserves activity for routine bench use; aliquoting the polyclonal stock limits freeze-thaw cycles and preserves titre over time.