Anti-KDM4A Antibody

Histone H3 lysine demethylases remodel chromatin at specific residues by oxidatively removing methyl groups. This unconjugated rabbit polyclonal reagent from Antibodies.com targets the KDM4A enzyme (also called JMJD2A or JHDM3A) and is supplied as a 100 µl liquid vial for in vitro research applications.

Validated uses include Western blot on cultured-cell lysates and immunohistochemistry on formalin-fixed tissue sections, with reactivity confirmed against Human and Mouse orthologs. Work with the antibody typically follows standard immunoblot and staining workflows: dilute to working concentration in blocking buffer for WB membrane probing, or apply to deparaffinized, antigen-retrieved tissue sections for IHC localization studies.

The target itself participates in hypoxia-driven transcription through HIF pathway cross-talk, the DNA-damage checkpoint, and androgen-receptor signaling in prostate cell models, making the reagent broadly useful for cancer-epigenetics studies, chromatin biochemistry screens, and developmental biology investigations.

Store refrigerated at 4°C for short-term use; for long-term storage, aliquot the vial contents and freeze to limit freeze-thaw cycling and preserve binding activity. The product is intended for research use only.