Anti-KDM3B Antibody

KDM3B (also called JMJD1B) is a JmjC-domain histone demethylase that removes mono- and dimethyl marks from histone H3 lysine 9, linking chromatin state to the transcription of metabolic and germline genes. The polyclonal reagent from Antibodies.com is raised in rabbit and supplied as 100 µl of unconjugated antiserum, formatted for western blot and immunohistochemistry workflows on human and mouse samples.

Loss or dysregulation of KDM3B activity has been reported in acute myeloid leukemia and in metabolic contexts such as adipogenesis, so laboratories working with this reagent commonly track expression changes, nuclear localisation, and chromatin-associated effects in those model systems. Because it is polyclonal, the antibody recognises multiple epitopes across the target, which can be useful when a single monoclonal clone fails to bind conserved regions in fixed tissue sections or under denaturing western blot conditions.

Researchers should confirm the recommended storage temperature, aliquot practice, and freeze-thaw limits on the supplied datasheet before first use, and pair the antibody with an appropriate horseradish peroxidase or chromogen detection system matched to the chosen application.