Anti-KCNJ2 Antibody

KCNJ2 encodes the Kir2.1 inward-rectifier potassium channel, a 427-amino-acid transmembrane protein that sets the resting membrane potential in cardiac myocytes and skeletal muscle fibers. Loss-of-function mutations in this gene underlie Andersen-Tawil syndrome type 1, a disorder marked by periodic paralysis, ventricular arrhythmias, and skeletal anomalies, while gain-of-function variants have been tied to short QT syndrome type 3 and familial atrial fibrillation, making reliable detection tools important for cardiovascular and neuromuscular research.

This rabbit polyclonal IgG antibody from Antibodies.com was raised against KCNJ2 and is validated for Western blot detection of human and mouse samples. It is supplied as 200 µL of unconjugated antiserum, suitable for probing endogenous Kir2.1 in cell lysates and tissue homogenates prepared from heart or skeletal muscle. The polyclonal format provides multi-epitope coverage, which can be valuable for recognizing different conformational states or processing intermediates of the channel when characterizing ion channel expression and regulation in excitable tissues.