Anti-KCND3 Antibody

Raised against the Kv4.3 voltage-gated potassium channel encoded by the KCND3 gene, this rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol as a 100 µl aliquot. The unconjugated antibody is validated for Western blot and immunohistochemistry on rodent tissue, supporting studies of cardiac repolarization, neuronal firing patterns, and the spinocerebellar ataxia subtypes SCA19 and SCA22 that are linked to KCND3 mutations. Glycerol-containing formulation protects the antibody from freeze-thaw damage during routine storage at -20 °C, while the azide preservative maintains shelf stability for short-term benchtop handling. Researchers use this reagent to map Kv4.3 subunit expression across brain regions and to investigate channel remodeling in models of arrhythmia and channelopathy.