Anti-KCNC3 Antibody

The Kv3.3 voltage-gated potassium channel (KCNC3) governs high-frequency action potential firing in fast-spiking cerebellar and hippocampal interneurons, making the subunit a focus of neuroscience research into ataxia and motor coordination. A rabbit polyclonal IgG from Antibodies.com targets a conserved region of KCNC3 to support these studies, supplied as 200 µl of unconjugated liquid reagent. This Primary Antibody is validated for Western blot detection in human, mouse, and rat samples, where the polyclonal format recognizes multiple epitopes across the protein to strengthen signal consistency in denatured lysate workflows.

Working aliquots are recommended for routine handling, with the stock vial stored at -20 °C to preserve activity through repeated freeze-thaw cycles; briefly refrigerated storage suits active aliquots during a typical experiment. Investigators studying spinocerebellar ataxia type 13 and related Kv3.3 channelopathies apply the reagent to characterize how KCNC3 mutations alter neuronal excitability and disrupt firing patterns. Each lot is purified to limit non-specific binding during chemiluminescent Western blot readout of membrane and cytosolic fractions from neural tissue, helping labs map subunit expression across the cerebellum, hippocampus, and brainstem.