Anti-KCNA1 Antibody

Generated in rabbit as an unconjugated polyclonal IgG, this Antibodies.com reagent targets the Kv1.1 voltage-gated potassium channel encoded by KCNA1, a membrane protein that shapes neuronal firing and cerebellar circuit behavior. The antibody is supplied as 200 µl of liquid in a vial and is validated for Western blot detection in human, mouse, and rat samples, supporting studies of channel expression across neural and peripheral tissues.

Laboratory groups investigating episodic ataxia type 1, peripheral nerve hyperexcitability, seizure susceptibility, and related inherited or acquired channelopathies commonly use this reagent to probe Kv1.1 levels in tissue lysates and transfected cell lines. Because the polyclonal format recognizes multiple epitopes on the target, signal is often preserved when the protein is partially denatured, post-translationally modified, or expressed at low abundance in the sample.

For routine use, aliquot the vial on first thaw, refrigerate the working stock, protect from light, and avoid repeated freeze-thaw cycles of the frozen stock to preserve antibody performance across replicate blots.