Anti-KCNA1 Antibody

The Kv1.1 voltage-gated potassium channel encoded by KCNA1 is a delayed-rectifier pore-forming alpha subunit that shapes action potential repolarization and modulates neuronal firing patterns throughout the central and peripheral nervous system. This polyclonal rabbit IgG reagent from Antibodies.com is raised against the KCNA1 protein and is validated for Western blot detection of the endogenous channel in human, mouse, and rat samples. Supplied as a 100 µl unconjugated vial, the antibody is intended for immunoblotting workflows that use denaturing gels and standard transfer conditions, with demonstrated reactivity across brain, dorsal root ganglion, and other neuronal tissue lysates. Investigators studying episodic ataxia type 1, the autosomal dominant channelopathy driven by KCNA1 loss-of-function mutations, use this reagent to compare expression levels between patient-derived lines and matched controls, as well as to characterize rodent disease models carrying engineered KCNA1 alleles. Additional research contexts include studies of epilepsy susceptibility, peripheral nerve conduction velocity, and synaptic transmission at central and neuromuscular junctions, where Kv1.1 surface density is tied to channel availability and excitability phenotypes. The polyclonal format raises the probability of recognizing multiple epitopes on the Kv1.1 subunit, which can be useful when comparing rodent knockouts with human post-mortem tissue samples that differ in glycosylation and other post-translational modifications.