Anti-KAT5 Antibody

Raised in rabbit, this polyclonal reagent from Antibodies.com targets KAT5, a MYST-family lysine acetyltransferase also known as TIP60 (HTATIP1). The unconjugated IgG antibody is supplied as a 50 µl volume and is validated for western blot, immunohistochemistry, and immunofluorescence applications across human, mouse, and rat samples. KAT5 acetylates histones H2A, H3, and H4, modifies H2AX at Lys15, and operates within the DNA damage response, ATM signaling, chromatin remodeling, and transcriptional regulation, making it a frequent target in cancer biology and neurodegeneration research. Because the antibody is polyclonal, it recognizes multiple epitopes on the target, supporting detection of splice variants and post-translational states where monoclonal clones may miss conformational or modified forms. Investigators use it to study apoptosis, cell-cycle checkpoints, and acetylation-dependent control of gene expression, including p53 pathway activation following genotoxic stress.