Anti-KALRN Antibody

This rabbit polyclonal antibody from Antibodies.com targets KALRN (Kalirin), a multifunctional Rho-GEF scaffolding protein implicated in cytoskeletal remodeling, dendritic spine morphogenesis, and NMDA receptor signaling at excitatory synapses. The reagent is supplied as 100 µl of purified IgG at 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, and is unconjugated for flexible downstream labeling with user-selected fluorophores or enzymes. It has been validated for Western blot and immunocytochemistry on samples derived from human, mouse, and rat, supporting neuroscience, cardiovascular, and cell signaling workflows. The polyclonal format provides broad epitope coverage across the major Kalirin isoforms (Kalirin-7, Kalirin-9, and Kalirin-12), enabling detection of both full-length and truncated variants in neuronal lysates, primary cultured neurons, and transfected cell lines. Store refrigerated at 4°C in the original vial; aliquot to limit freeze-thaw cycles of the glycerol-free formulation, and protect from prolonged light exposure. Each vial is intended for research use only and is suited to investigators studying RhoA/Rac1-mediated pathways, schizophrenia-associated signaling, ischemic stroke models, and synaptogenesis.