Anti-JNK1 + JNK2 + JNK3 Antibody [Assigned #A11119]

This rabbit monoclonal antibody from Antibodies.com is raised against the c-Jun N-terminal kinase (JNK) family and recognizes all three isoforms — JNK1 (MAPK8), JNK2 (MAPK9), and JNK3 (MAPK10) — as a single reagent. The unconjugated IgG clone is supplied in a 50 µl volume and is validated for Western blot, immunofluorescence, and immunoprecipitation workflows.

JNK kinases are stress-activated serine/threonine kinases that phosphorylate c-Jun and related transcription factors, driving cellular responses to cytokines, oxidative stress, and DNA damage. Their involvement in apoptosis, inflammation, and metabolic signaling makes pan-JNK detection useful in studies of neurodegeneration, tumor progression, and immune cell activation. Because JNK3 is largely brain-restricted while JNK1 and JNK2 are broadly expressed, a reagent that simultaneously captures all three gives a more complete view of pathway activity across tissues and model systems.

The antibody shows reactivity with human, mouse, rat, bovine, canine, monkey, and zebrafish samples, supporting cross-species work in cell lines, primary cultures, and whole-tissue lysates. Store refrigerated and protect from light to preserve activity; aliquot on first use to limit freeze-thaw cycles. For research use only.