Anti-JIP3 Antibody

This unconjugated rabbit polyclonal antibody from Antibodies.com targets JIP3 (also known as MAPK8IP3), a scaffold protein that assembles components of the c-Jun N-terminal kinase (JNK) signaling cascade. The reagent is supplied in a 100 µl volume and is unconjugated, allowing researchers flexibility in choosing secondary labels for their assay. It is validated for western blot and immunofluorescence applications, with demonstrated reactivity against human JIP3. JIP3 also functions outside canonical JNK signaling by interacting with kinesin light chains to mediate anterograde vesicle transport along microtubules, making this reagent useful for studies of neuronal trafficking, stress-activated kinase signaling, and MAPK8IP3-linked neurodevelopmental disease research. The polyclonal format provides recognition of multiple epitopes on the target protein, which can be advantageous when detecting full-length JIP3 across varying expression contexts in cell and tissue samples.