Anti-JIP-1 (A99) Antibody

This polyclonal antibody from Antibodies.com targets JIP-1 (JNK-interacting protein 1, also known as MAPK8IP1), a scaffold protein that organizes components of the JNK and p38 MAPK signaling cascades in neurons and other cell types. The reagent is raised in rabbit and supplied as an unconjugated IgG preparation at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide, with a working volume of 50 ul per vial. Validated applications include western blot and immunohistochemistry, where the antibody detects endogenous JIP-1 in lysates and fixed sections prepared from human, mouse, and rat samples. Researchers studying stress-activated kinase signaling, axonal transport, amyloid precursor protein trafficking, and neurodegeneration use this reagent to map JIP-1 distribution in brain tissue and to monitor expression changes following cytokine stimulation or excitotoxic challenge. Storage at 4 degrees C in the supplied buffer preserves activity for routine short-term use; for longer projects, aliquot the contents and freeze to limit freeze-thaw cycles. Sodium azide at 0.05% prevents microbial contamination of the working solution.