Anti-JAM-B Antibody

Junctional Adhesion Molecule B (JAM-B), also known as JAM2 or VE-JAM, is a type I transmembrane glycoprotein of the immunoglobulin superfamily that localizes to tight junctions of endothelial and epithelial cells and contributes to leukocyte transmigration, cell-cell adhesion, and the maintenance of vascular permeability barriers. This unconjugated rabbit polyclonal reagent from Antibodies.com was raised against human JAM-B and is validated for Western blot and immunohistochemistry workflows, supporting studies of angiogenesis, inflammation, and spermatogenesis where the protein's distribution and post-translational status are of interest.

Supplied as a 100 µl liquid vial, the antibody binds the human target with the polyclonal diversity that helps recognize multiple epitopes across denatured and native protein conformations. Researchers commonly apply it to whole-cell lysates and paraffin or frozen tissue sections to map JAM-B expression on endothelial cells, lymphocytes, and at sites of intercellular junctions, then pair it with anti-rabbit secondary reagents for chromogenic or fluorescent detection. Refrigerated storage with aliquoting before use preserves activity across multiple freeze-thaw cycles.

From Antibodies.com, this primary antibody is intended for research use only and serves as a practical option for laboratories characterizing JAM-B expression in vascular biology, immune cell trafficking, and tumor microenvironment studies.