Anti-JAK2 (phospho-Y570) Antibody

This rabbit polyclonal reagent from Antibodies.com is raised against Janus Kinase 2 phosphorylated at tyrosine 570, a regulatory site whose modification status is widely used to interrogate cytokine-driven JAK/STAT signalling in primary cells and cultured lines. The antibody is supplied as 100 µl of an affinity-purified fraction at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, and is validated for Western blot detection of the phospho-Y570 band in lysates prepared under standard reducing conditions. Cross-reactivity has been confirmed against human, mouse, and rat JAK2, making it useful for comparative work in cell-line models and rodent tissue, while the unconjugated format allows laboratories to pair it with their preferred HRP- or fluorophore-conjugated reporter secondary. For handling, aliquot upon first thaw to limit freeze-thaw cycles, snap-freeze in working volumes, and store the unused fraction at -20°C protected from light; sodium azide is included as a preservative, so the reagent is not compatible with live-cell or in vivo work without prior dialysis. Researchers investigating erythropoietin or interferon signalling, myeloproliferative neoplasm biology, or kinase-substrate phosphorylation dynamics will find this reagent a focused tool for tracking the Y570 site specifically rather than total JAK2 levels.