Anti-JAK2 Antibody

Janus kinase 2 (JAK2) is a cytoplasmic non-receptor tyrosine kinase that couples type I cytokine receptors to the JAK/STAT signal transduction cascade, and Antibodies.com supplies this rabbit host polyclonal primary antibody for research detection of the human, mouse, and rat target. The unconjugated reagent is provided at 1 mg/ml in Phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, and each 100 µL vial is intended for western blot (WB) and immunohistochemistry (IHC) workflows in oncology, hematology, and cytokine signaling studies. The antibody is suited to investigation of the JAK2 V617F gain-of-function mutation associated with myeloproliferative neoplasms including polycythemia vera and essential thrombocythemia. For short-term storage, refrigerate at 4°C; for long-term storage, freeze working aliquots at -20°C and minimize freeze-thaw cycles to preserve activity.