Anti-ITI-H3 Antibody

Raised in rabbit against the human ITIH3 protein, this polyclonal primary antibody from Antibodies.com is supplied as 100 µl of unconjugated serum. ITIH3 (Inter-alpha-Trypsin Inhibitor Heavy Chain 3) is a secreted glycoprotein that becomes covalently linked to hyaluronan in the extracellular matrix, where it contributes to matrix stabilization and acute-phase inflammatory responses.

Validated for Western blot and immunohistochemistry on human samples, the reagent yields a band near the predicted molecular weight of the target in lysate blots and a strong cytoplasmic signal in fixed tissue sections. It is shipped as a liquid aliquot in a vial with no fluorophore or enzyme conjugate attached, leaving the user free to pair it with anti-rabbit secondary reagents for chromogenic, fluorescent, or biotin-streptavidin detection.

Common research uses include studies of extracellular matrix remodeling, hepatic and inflammatory biology, and investigation of the ITIH3 locus, which has been linked to schizophrenia susceptibility and circulating plasma protein levels in published genome-wide association studies. Because the reagent is polyclonal, it tolerates minor sequence variation between isoforms and post-translational modifications of the target.