Anti-ITGB4 (Ab-1510) Antibody

ITGB4 (Integrin Subunit Beta 4) pairs with integrin alpha-6 to form the α6β4 heterodimer, a transmembrane receptor that anchors epithelial cells to the underlying basement membrane through hemidesmosomes. Tyrosine 1510 sits within the cytoplasmic tail and serves as a regulatory phosphorylation site; modification at this residue alters downstream signaling linked to cell adhesion, migration, and invasion. This polyclonal antibody from Antibodies.com was raised in rabbit and selectively recognizes the Ab-1510 epitope on human ITGB4, making it applicable to studies of epithelial biology, hemidesmosome assembly, wound healing, and tumor progression in carcinomas.

The reagent is unconjugated and supplied as 100 µl of antiserum, providing enough material for multiple Western blot and immunohistochemistry experiments on human tissue sections or cell lysates. Polyclonal recognition expands the spectrum of epitopes detected, which can help when probing full-length ITGB4 (~200 kDa) in samples where monoclonal reagents fail to bind consistently. Researchers investigating epidermolysis bullosa, squamous cell carcinoma, or integrin-mediated signaling pathways frequently use affinity tools directed to this region of the cytoplasmic domain.