Anti-ITGA5 Antibody

This polyclonal antibody from Antibodies.com targets the integrin alpha-5 subunit (ITGA5), the alpha component of the heterodimeric fibronectin receptor that pairs with integrin beta-1 (ITGB1) on the cell surface. Raised in rabbit, the IgG reagent is unconjugated and validated for Western blot and immunohistochemistry on human samples. Researchers use it to investigate fibronectin-mediated adhesion, migration, and signaling pathways in contexts such as wound healing, angiogenesis, tumor invasion, and extracellular matrix interactions. The ITGA5/CD49e protein forms part of the VLA-5 complex and is upregulated in many solid tumors, including breast, ovarian, and colorectal cancers, making the antibody a useful tool for studying tumor-stroma interactions and metastasis. The reagent is supplied as 100 µl of liquid antiserum in a vial, and aliquoting is recommended to limit repeated freeze-thaw cycles. For research use only.