Anti-ITGA2B Antibody

Produced in rabbit as a polyclonal IgG and supplied by Antibodies.com at 200 µl per vial, this unconjugated reagent binds ITGA2B (Integrin subunit alpha 2b, also referred to as CD41 or GPIIb), the platelet-specific fibrinogen receptor component that heterodimerizes with integrin beta 3 to constitute the GPIIb/IIIa complex driving platelet aggregation. Reactivity is confirmed for human and mouse samples, making the antibody useful for studies of megakaryocyte maturation, thrombus biology, and Glanzmann thrombasthenia model systems. Antibodies.com validates this reagent for Western blot and immunofluorescence, where the polyclonal epitope coverage helps capture both full-length and proteolytically processed forms of the target. Standard applications include immunoblotting of platelet lysates and immunofluorescent staining of megakaryocyte cultures or fixed blood smears, with HRP- or fluorophore-tagged secondaries supplying detection. Storage at 4 °C is appropriate for working aliquots; for extended shelf life, freezing at -20 °C in single-use aliquots is recommended and repeated freeze-thaw cycles should be avoided to maintain titer. The format is a research use only reagent intended for hematology, vascular biology, and cardiovascular research laboratories investigating integrin function and platelet-related pathology.