Anti-Islet cell autoantigen 1 Antibody

This unconjugated rabbit polyclonal antibody targets Islet cell autoantigen 1 (ICA1), a protein originally identified through islet cell expression studies and now actively investigated for its role in Type 1 Diabetes autoimmunity and broader endocrine research. Produced in rabbits and supplied at 100 µg per vial, the reagent is validated for western blot (WB) and immunohistochemistry (IHC) workflows on human samples, supporting studies of pancreatic islets and selected neural tissues where the endogenous antigen is normally expressed.

Each lot is affinity-purified to reduce nonspecific background and shipped refrigerated for immediate use. For longer storage, aliquoting and freezing at -20°C preserves activity across multiple freeze-thaw cycles. The unconjugated format allows researchers to pair the antibody with custom detection chemistries, including fluorescent secondary reagents or HRP-based systems, depending on the desired readout. Each laboratory should optimize working dilutions against its own positive-control tissue or cell lysate, and reactivity is reported for human samples only.

Part of the Primary Antibodies portfolio from Antibodies.com, this reagent complements autoimmune diabetes panels alongside antibodies against GAD, IA-2, and insulin, and supports basic research into beta-cell biology, secretory granule function, and the broader set of proteins targeted by islet cell autoantibodies in Type 1 Diabetes research. It is intended for research use only and is not approved for diagnostic procedures.