Anti-ISG15 Antibody

Raised in rabbit against ISG15, an interferon-stimulated 17 kDa ubiquitin-like modifier central to innate antiviral defense, this polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, presented as a 100 µl vial. The antibody is validated for Western blot and immunohistochemistry on human and mouse samples, and the unconjugated format allows flexible pairing with fluorescent, chromogenic, or chemiluminescent secondary reagents. ISG15 is strongly induced by type I interferons and becomes conjugated to substrate proteins through the ISGylation cascade, so this reagent is commonly used to study viral restriction, JAK/STAT signaling, tumor biology, and inflammatory pathways. The 50% glycerol cryoprotectant buffer lets the vial be stored refrigerated and protects activity through routine freeze-thaw cycles, while the polyclonal mixture improves the chance of detecting multiple ISG15 epitopes, including both free and conjugated forms.