Anti-ISCU Antibody

Produced in rabbit as a polyclonal IgG preparation, this unconjugated primary antibody from Antibodies.com targets the iron-sulfur cluster scaffold protein ISCU, a mitochondrial scaffold essential for Fe-S cluster biogenesis. The reagent is validated for Western Blot detection of human and mouse ISCU and is supplied as 100 µl of liquid ready for use in standard immunoblotting workflows. ISCU plays a critical role in mitochondrial [2Fe-2S] and [4Fe-4S] cluster assembly, with dysfunction linked to myopathy with exercise intolerance and Friedreich's ataxia, making it a target of interest in studies of mitochondrial metabolism, iron homeostasis, and neuromuscular disease research. The polyclonal format allows recognition of multiple epitopes on the ISCU protein, supporting consistent signal in denatured lysate samples. Storage at 4°C is recommended for short-term use, with aliquoting recommended for long-term storage at -20°C to preserve antibody activity across repeated freeze-thaw cycles.