Anti-IRTKS Antibody

IRTKS (Insulin Receptor Tyrosine Kinase Substrate) functions as an adapter protein connecting insulin receptor signaling to actin cytoskeleton remodeling at membrane ruffles and lamellipodia. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against IRTKS and validated for western blot, immunohistochemistry, and ELISA workflows across human, mouse, and rat samples. Each vial supplies 100 µl of polyclonal antiserum for dilution into standard immunodetection buffers.

Researchers studying membrane dynamics, insulin-stimulated cytoskeletal rearrangements, or signaling downstream of receptor tyrosine kinases use this reagent to track endogenous IRTKS expression patterns. In western blot the antibody detects the expected IRTKS band from cell lysates; in IHC it labels tissues with cytoplasmic and membrane-associated localization that reflects IRTKS recruitment to sites of actin reorganization. ELISA compatibility extends the reagent to quantitative antigen detection in screened samples.

The polyclonal antibody is produced under standard immunization protocols in a rabbit host, and the unconjugated format allows secondary antibody pairing flexibility for chromogenic or fluorescent detection chemistries. This supports research applications in cell biology, neurobiology, and metabolic disease modeling. The product is shipped in liquid form for convenient storage and handling, with technical documentation provided by Antibodies.com to help optimize titer for individual assay conditions.