Anti-IRS1 (phospho S639) Antibody

Generated in rabbit and raised against a phosphopeptide corresponding to serine 639 of human Insulin Receptor Substrate 1, this unconjugated polyclonal IgG primary antibody from Antibodies.com is supplied as 200 µl of liquid and is validated for Western blot (WB) and immunohistochemistry (IHC) applications.

IRS1 is a central adaptor in insulin and IGF-1 receptor signaling, and serine 639 phosphorylation is mediated primarily by mTORC1 and S6K1 kinase activity. This modification is a well-characterized marker of negative feedback on insulin signaling and is widely used in studies of insulin resistance, type 2 diabetes, and metabolic disease research.

The reagent has been validated on human, mouse, and rat samples, supporting cross-species work in cell line models and tissue sections. For research use only.