Anti-IRS1 (phospho S639) Antibody

The Antibodies.com Anti-IRS1 (phospho S639) polyclonal antibody is a research-grade rabbit IgG reagent that specifically recognizes Insulin Receptor Substrate 1 only when phosphorylated at the serine 639 residue. This site is a well-characterized target of S6K1 / p70 ribosomal protein kinase activity downstream of mTORC1, making the reagent a useful tool for dissecting nutrient-sensing and insulin-signaling cascades in metabolic-disease models.

Validated for Western blot and immunohistochemistry, the antibody detects endogenous IRS1 phospho-S639 in human, mouse, and rat samples, supporting cross-species studies of insulin resistance, type 2 diabetes, obesity, and mTOR-pathway dysregulation in tumor biology. Supplied as 100 µl of unconjugated antiserum, the reagent is compatible with standard chemiluminescent, fluorescent, and chromogenic detection workflows, and can be paired with species-matched secondary antibodies for double-labeling experiments.