Anti-IRS-1 (G630) Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com was raised against the G630 region of Insulin Receptor Substrate 1 (IRS-1), a cytoplasmic adaptor that couples activated insulin and IGF-1 receptors to downstream PI3K/Akt and Ras/MAPK signaling cascades. Validated for immunohistochemistry (IHC) and immunofluorescence (IF), it cross-reacts with human, mouse, and rat IRS-1, supporting comparative studies of insulin-receptor signaling in metabolic disease, oncology, and neurobiology models where YXXM-motif phosphorylation is being mapped in fixed tissues. The antibody is supplied at a 50 µl sample volume, formulated at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, and should be refrigerated to preserve activity; aliquot before use if repeated freeze-thaw cycles are anticipated. The polyclonal format recognizes multiple epitopes within the target region, providing broader coverage than a monoclonal clone when probing endogenous IRS-1 distribution in primary cells and tissue sections.