Anti-IRS-1 (D606) Antibody

Insulin receptor substrate 1 (IRS-1) is a cytoplasmic signaling adapter phosphorylated by the activated insulin receptor, coupling it to downstream PI3K/Akt and MAPK cascades that govern glucose uptake, cell growth, and survival.

This rabbit polyclonal reagent from Antibodies.com, raised against the D606 region of IRS-1, is supplied unconjugated at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at pH 7.2 as a 100 µl volume for western blot and immunohistochemistry workflows.

Validated reactivity spans human, mouse, and rat samples, making the antibody useful for insulin resistance research, type 2 diabetes models, and growth-factor signaling studies in cell culture and in vivo systems where mapping receptor-substrate localization informs metabolic and oncology investigations.