Anti-IRS-1 Antibody

Insulin Receptor Substrate 1 (IRS-1) is a roughly 131 kDa cytoplasmic adaptor protein that is tyrosine-phosphorylated by the activated insulin receptor and relays downstream PI3K/Akt signaling, and this unconjugated rabbit polyclonal reagent from Antibodies.com is raised against it. Supplied as 100 µl of antiserum, the antibody is validated for western blot, immunohistochemistry, and ELISA detection across human, mouse, and rat samples. Researchers studying insulin resistance, metabolic disease models, obesity-related pathways, and IGF-1 growth-factor signaling can pair the unconjugated format with HRP-, biotin-, or fluorophore-labelled secondary antibodies for chromogenic, chemiluminescent, or immunofluorescence readouts on whole-cell lysates, tissue sections, and fixed samples.