Anti-IRS-1 Antibody

Raised in rabbit against Insulin Receptor Substrate 1 (IRS-1), this unconjugated polyclonal reagent is supplied by Antibodies.com as a 100 µl aliquot and is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows. It recognizes endogenous IRS-1 in human, mouse, and rat samples, supporting studies of insulin and IGF-1 receptor signaling, metabolic regulation, and downstream PI3K/Akt pathway activity. The polyclonal format allows recognition of multiple epitopes on the adaptor protein, which is useful when probing post-translationally modified or alternatively spliced variants of this receptor substrate. Researchers investigating diabetes, obesity, growth-factor responses, and mechanisms of insulin resistance use the antibody to track receptor-substrate phosphorylation status and tissue-level expression patterns in cultured cells, fixed sections, and lysate preparations. Supplied in a standard research-use volume, the reagent integrates into routine immunodetection pipelines that examine upstream insulin signaling and downstream effectors.