Anti-IRGM Antibody

IRGM (Immunity-Related GTPase M) is a P-loop GTPase that regulates autophagy, mitochondrial fission, and clearance of intracellular pathogens such as Mycobacterium tuberculosis and adherent-invasive Escherichia coli. Genetic variation at the IRGM locus has been linked through genome-wide association studies to Crohn's disease susceptibility and to outcomes across infectious disease research, making this target broadly relevant to immunology, microbiology, and inflammation programs.

This unconjugated rabbit polyclonal IgG reagent is supplied by Antibodies.com as a 100 µl liquid aliquot and is validated for two complementary workflows: Western blot detection of endogenous IRGM in cell lysates, and immunohistochemistry localization in formalin-fixed paraffin-embedded tissue sections. The antibody recognizes IRGM from human, mouse, and rat sources, supporting translational studies that pair rodent disease models with human biopsy material.

Working dilutions should be titrated for each application and detection system. For short-term use, keep the vial refrigerated; for longer projects, aliquot the antibody and freeze to limit freeze-thaw damage. Intended for research use only.