Anti-IRF8 Antibody

This polyclonal antibody from Antibodies.com targets Interferon Regulatory Factor 8 (IRF8), a transcription factor of the IRF family that governs myeloid lineage commitment, macrophage and dendritic cell differentiation, and the interferon-driven antimicrobial response. Raised in rabbit and supplied as an unconjugated reagent, it is validated for Western blot (WB) and immunohistochemistry (IHC) on human and mouse samples, supporting studies of innate immunity, B-cell maturation, and the tumor-suppressor activity IRF8 exerts in myeloid leukemias and certain lymphomas.

The antibody is provided at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% glycerol as a stabilizer, shipped as a 100 µl vial, and is suitable for chromogenic IHC on formalin-fixed paraffin-embedded sections as well as standard immunoblotting of whole-cell and nuclear extracts. For storage, keep the vial refrigerated at 4 degrees C; avoid repeated freeze-thaw cycles and protect from prolonged light exposure to preserve binding activity. Researchers working on chronic myelogenous leukemia, monocyte/macrophage biology, and interferon signalling pathways will find this reagent a reliable tool for detecting endogenous IRF8 protein across human and murine experimental systems.