Anti-IRAK4 Antibody

Rabbit polyclonal reagent raised against Interleukin-1 Receptor-Associated Kinase 4 (IRAK4), supplied by Antibodies.com as a 100 µl vial at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol. The unconjugated antibody binds endogenous IRAK4 and is validated for Western blot (WB) and immunohistochemistry (IHC), with cross-reactivity confirmed against human, mouse, and rat samples. IRAK4 acts downstream of Toll-like and IL-1 family receptors, transducing MyD88-dependent signals that drive NF-κB and MAPK activation in innate immune cells, which makes this reagent useful for studies of inflammation, sepsis signaling, and primary immunodeficiency. Aliquoting on receipt and storage at -20 °C preserves activity and limits freeze-thaw damage to the polyclonal pool. Suitable for researchers probing TLR/IL-1R pathway activity, kinase signaling cascades, and immune cell activation in cell lysates and fixed tissue sections.