Anti-IRAK3 Antibody

The IRAK3 polyclonal antibody from Antibodies.com is a rabbit-hosted, unconjugated reagent raised against Interleukin-1 Receptor-Associated Kinase 3 (IRAK-M), a serine/threonine kinase that acts as a negative regulator of Toll-like receptor signaling in innate immune cells. Supplied at 100 µl per vial, this primary antibody specifically detects human IRAK3 and is validated for western blot and immunofluorescence workflows, supporting studies of macrophage and monocyte signaling, endotoxin tolerance, and the regulatory pathways that control inflammatory cytokine responses.

IRAK3 is induced upon lipopolysaccharide stimulation and restrains downstream IRAK1 and IRAK4 activation at the receptor complex, making this reagent useful for researchers investigating sepsis biology, chronic inflammatory conditions, and the molecular basis of innate immune cell reprogramming. The unconjugated format allows users to pair the antibody with custom fluorophore or enzyme labels suited to their preferred detection chemistry. For short-term use, store at 4 °C; for longer-term storage, aliquot and freeze to preserve activity across multiple experiments.