Anti-IRAK3 Antibody

This rabbit polyclonal antibody from Antibodies.com targets IRAK3 (Interleukin-1 Receptor-Associated Kinase 3), a serine/threonine kinase that negatively regulates Toll-like receptor and interleukin-1 receptor signaling in innate immune cells. Raised in rabbit and supplied as 50 µl of unconjugated reagent, it is validated for western blot and immunohistochemistry applications and is reactive with human samples. IRAK3 is predominantly expressed in monocytes, macrophages, and other myeloid lineages, where it dampens inflammatory signaling and contributes to immune tolerance, making it relevant to studies of sepsis, autoimmune disease, and tumor-associated macrophage biology. The polyclonal format offers epitope diversity that supports detection of the full-length kinase in cell lysates and fixed tissue sections. Storage at -20°C in small aliquots helps preserve antibody activity and minimize freeze-thaw loss across repeated experiments. Researchers commonly use this reagent to assess IRAK3 induction following LPS stimulation, to compare expression in M1 versus M2 macrophage polarization models, and to localize the protein within tissue microenvironments by IHC.