Anti-IRAK3 Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets Interleukin-1 Receptor-Associated Kinase 3 (IRAK3), a serine/threonine kinase that negatively regulates Toll-like receptor and IL-1 receptor innate immune signaling in monocytes, macrophages, and other myeloid cells.

Supplied at 100 µL per vial as unconjugated antiserum in a buffered solution containing sodium azide as preservative, the reagent is validated for western blot and immunohistochemistry workflows on human samples, supporting detection of the endogenous ~68 kDa cytoplasmic protein in cell lysates, tissue sections, and primary monocyte or macrophage preparations.

Researchers investigating innate immune tolerance, sepsis, tumor-associated macrophage biology, and chronic inflammatory disease models use this reagent to characterize IRAK3 expression patterns and to dissect feedback inhibition of MyD88-dependent signaling. The unconjugated format allows flexible pairing with HRP-, biotin-, or fluorophore-conjugated secondary antibodies to suit chromogenic, fluorescence, or tyramide signal-amplification protocols. For best results, store working aliquots frozen at -20 °C, protect from light, and limit repeated freeze-thaw cycles of the stock vial.