Anti-iPLA2γ Antibody

This rabbit polyclonal antibody targets iPLA2γ (PNPLA8), a calcium-independent phospholipase A2 isoform anchored to mitochondrial outer membranes. The reagent is supplied as 100 µl of unconjugated antiserum and is validated for Western blot and ELISA workflows with human and mouse samples. Antibodies.com distributes this reagent within its primary antibody catalog.

iPLA2γ contributes to mitochondrial lipid remodeling, including the acyl-chain editing of cardiolipin, and has been studied in the context of ferroptosis, oxidative stress responses, and neurodegeneration. The polyclonal format raises the probability of recognizing several epitopes on the target, which can be useful when probing post-translational modifications or conformational variants of the protein.

For Western blot, the antibody is applied to cell lysates and tissue homogenates to detect endogenous iPLA2γ. The unconjugated presentation allows researchers to pair the antibody with their preferred secondary reagent and detection chemistry. Aliquoting upon receipt and storage at -20°C is recommended to preserve activity across multiple freeze-thaw cycles.