Anti-Involucrin Antibody

Raised in rabbit against the human Involucrin protein, this polyclonal reagent from Antibodies.com supports research into epidermal differentiation and cornified envelope assembly. The unconjugated antibody is supplied as 100 µL of ready-to-titrate stock and has been validated for western blot and immunohistochemistry workflows on human tissue sections, where it is commonly used to confirm squamous epithelial identity and keratinocyte maturation state in skin, oral mucosa, and cervical biopsy samples. Because Involucrin expression rises as basal keratinocytes commit to terminal differentiation, the reagent is frequently paired with cytokeratin markers in studies of barrier formation, wound re-epithelialization, and stratified epithelium models. Investigators working on psoriatic lesions, oral squamous cell carcinoma, and cervicovaginal cytology specimens also rely on this antibody to distinguish differentiated from undifferentiated epithelial compartments. Host species reactivity is restricted to Human, and the polyclonal format provides broad epitope coverage across the central repeat domain of the target protein. The unconjugated format allows flexible choice of secondary reporter, whether HRP, fluorescence, or biotin-based detection, making the antibody compatible with both chromogenic IHC and immunofluorescence imaging on paraffin-embedded or frozen sections.