Anti-INTS6 Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody from Antibodies.com targets Integrator Complex Subunit 6 (INTS6), a nuclear component of the Integrator multiprotein complex best known for its role in 3' end processing of small nuclear RNAs (snRNAs) and in transcription termination events linked to RNA polymerase II. The antibody is supplied at 100 µl and is validated for Western blot and immunofluorescence across human, mouse, and rat samples, making it useful for comparative studies of INTS6 expression and sub-nuclear localization in cell lines and primary tissue.

INTS6 was originally identified as DICE1 (deleted in cancer 1) and has since been investigated in hepatocellular carcinoma, gastric cancer, and lung adenocarcinoma contexts, where reduced expression has been linked to altered cell proliferation and tumor progression. Researchers use this reagent to probe INTS6 levels in nuclear and whole-cell lysates by Western blot, typically observing the expected band near 70 kDa, or to map sub-nuclear distribution by immunofluorescence in fixed cells. The unconjugated format allows flexible pairing with custom secondary labels for multiplex imaging or with HRP- and fluorophore-conjugated secondaries for standard detection workflows.

Recommended storage is at -20 °C in working aliquots to limit freeze-thaw cycles, and the reagent is intended for research use only. Host species, clonality, conjugate status, and reactivity profile are listed in the product specifications to support batch-to-batch reproducibility in chromatin, snRNA-processing, and cancer biology workflows.