Anti-INTS5 Antibody

Raised in rabbit and supplied as a polyclonal IgG preparation, this unconjugated reagent from Antibodies.com is specific for Integrator Complex Subunit 5, an approximately 108 kDa protein component of the multi-subunit Integrator complex that associates with U1 and U2 small nuclear RNAs and supports the 3' end maturation of snRNA transcripts transcribed by RNA polymerase II. Each 50 µl vial is delivered unconjugated for direct Western blot detection of endogenous INTS5 protein in validated human and mouse samples, and the polyclonal format recognizes multiple epitopes on the target to support consistent band patterns across cell line and primary tissue lysates. Investigators studying snRNA biogenesis, transcription termination, and developmental gene regulation rely on this reagent to probe Integrator complex function, particularly when comparing expression across engineered human cell lines and mouse model tissues that perturb snRNA processing. The glycerol-containing liquid formulation should be aliquoted upon receipt and stored frozen to limit freeze-thaw cycles and maintain antibody activity across multiple experiments. Because cross-reactivity with species outside the validated reactivity panel has not been characterized, the reagent is best deployed in the human and mouse Western blot workflows for which it has been validated, giving laboratories a focused tool for profiling Integrator-dependent RNA processing events and tracking INTS5 band intensities under varying transcriptional and developmental conditions.