Anti-Interleukin-1 receptor antagonist Antibody

Raised in rabbit against the endogenous human interleukin-1 receptor antagonist (IL-1Ra), this unconjugated polyclonal reagent from Antibodies.com is supplied at 100 µg and is validated for western blot and immunohistochemistry workflows on human samples. IL-1Ra is a soluble cytokine-binding protein that competitively blocks the type I IL-1 receptor, dampening pro-inflammatory signaling driven by IL-1α and IL-1β, and the antibody therefore supports studies of innate immune regulation, autoinflammatory disease models, and tissue-level expression patterns in fixed and frozen sections. As a polyclonal reagent, the antibody recognizes multiple epitopes on the IL-1Ra molecule, which is advantageous when probing denatured targets on membranes or formalin-fixed paraffin-embedded tissue. For bench handling, aliquot the working stock and store refrigerated to minimize repeated freeze-thaw cycles. Researchers investigating rheumatoid arthritis, vasculitis, or IL-1-driven tumor microenvironments can apply this reagent to confirm expression of the IL1RN gene product at the protein level.