Anti-Integrin α3 Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets the Integrin α3 subunit (also known as ITGA3 and CD49c), a transmembrane adhesion receptor that pairs with β1 integrin to bind laminins in basement membranes. Raised in rabbit and supplied as an unconjugated reagent, it is provided as 100 µl of liquid and validated for Western blot and ELISA workflows.

Integrin α3 contributes to epithelial sheet integrity, kidney glomerular basement-membrane organization, and signaling downstream of cell–matrix adhesion, so the reagent is frequently applied to studies of podocyte biology, lung epithelial development, and epidermal adhesion. Detection across Human, Mouse, and Rat samples supports comparative work in tissue lysates and primary cell models, including human podocytes and rodent lung or kidney tissue. Aliquot upon receipt and store refrigerated to preserve activity; avoid repeated freeze-thaw cycles.

The polyclonal format provides multi-epitope recognition, which can be useful when target abundance is limited or when a single monoclonal fails to detect processed forms of the receptor. Researchers working on ITGA3 mutations associated with interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa can pair this antibody with downstream immunoblotting to assess protein-level changes in patient-derived or model-system samples.