Anti-INSR (phospho Y1345) Antibody

Rabbit polyclonal IgG antibody raised against the Insulin Receptor (INSR), specifically recognizing the phosphorylated tyrosine 1345 epitope. This unconjugated primary reagent from Antibodies.com is validated for Western Blot and detects endogenous INSR in human, mouse, and rat samples. Y1345 is a documented autophosphorylation site on the cytoplasmic portion of the receptor, and detection of phospho-Y1345 is used to monitor ligand-stimulated insulin signaling.

Each vial of 50 µl is supplied as an unconjugated antiserum, allowing flexible selection of secondary labels and detection chemistries. The antibody is generated in rabbit and is of the IgG isotype, suitable for standard immunodetection workflows. Store at -20 °C in small aliquots to limit freeze-thaw cycles and preserve phospho-specific binding activity.

Researchers studying insulin action, glucose metabolism, receptor tyrosine kinase signaling, and metabolic disease models use this reagent to probe activation-state-specific INSR responses in cell lysates and tissue homogenates. The polyclonal format provides robust signal across multiple epitopes surrounding the phospho-Y1345 site, supporting reproducible detection in Western Blot applications.