Anti-INSR (phospho Y1146) + IGF1R (phospho Y1131) Antibody

Phospho-specific reception profiling across two receptor tyrosine kinases is delivered in a single rabbit polyclonal reagent raised against the activated autophosphorylation sites of the insulin receptor at tyrosine 1146 and the insulin-like growth factor 1 receptor at tyrosine 1131. Working in Western blot workflows, the unconjugated IgG resolves dual-band phospho-signaling patterns downstream of insulin and IGF-1 stimulation, allowing side-by-side comparison of PI3K/AKT and MAPK pathway activation in lysates from human, mouse, and rat sources. Each vial is supplied as 50 µl of polyclonal antibody, stored at -20°C to preserve phospho-epitope recognition, and is validated on insulin-stimulated versus untreated control lysates to confirm specificity at the targeted phosphotyrosines. From Antibodies.com, this reagent supports research into insulin resistance, metabolic dysfunction, and growth-factor-driven tumor biology by providing a unified read-out of receptor activation states.