Anti-IMPDH2 Antibody

The Antibodies.com rabbit polyclonal reagent targets IMPDH2 (Inosine-5'-monophosphate dehydrogenase 2), the rate-limiting enzyme of de novo guanine nucleotide biosynthesis and a clinically relevant target of mycophenolic acid-based immunosuppressants. This unconjugated primary antibody is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, a formulation that tolerates freezer storage and repeated freeze-thaw cycles in routine laboratory use. The 100 µL pack size suits multi-assay workflows in cell biology and immunology laboratories.

Validated for western blot, immunohistochemistry, and immunofluorescence, the reagent recognizes the human antigen and cross-reacts with mouse and rat orthologues, enabling comparative studies across standard model organisms. Researchers investigating lymphocyte proliferation, nucleotide metabolism, viral replication, or oncogenic guanine biosynthesis pathways rely on IMPDH2 detection to track expression changes under drug perturbation, gene knockdown, or disease-relevant cellular stress.

As a polyclonal reagent raised in rabbit, the antibody binds multiple epitopes on IMPDH2, which improves tolerance for partial protein denaturation during western blot workflows. The unconjugated format leaves the choice of secondary reporter, including HRP, fluorophore, or biotin, to the user, allowing the same lot to be redeployed across chromogenic IHC, immunofluorescence imaging, and standard western blot membranes. Aliquot upon first thaw to limit freeze-thaw exposure and protect activity over the working shelf life.