Anti-IMPA2 Antibody

Targeting the IMPA2 protein, this rabbit polyclonal reagent supports detection of inositol monophosphatase 2 across both Western blot and immunofluorescence workflows. The unconjugated IgG format lets investigators pair it with their preferred secondary detection system, and the polyclonal profile helps preserve signal when IMPA2 expression is low or when working with limited sample material.

IMPA2 encodes a magnesium-dependent phosphatase that hydrolyzes myo-inositol monophosphate in the phosphatidylinositol signaling pathway, a metabolic step relevant to lithium-responsive signaling and to phosphoinositide cycle studies in neuronal and peripheral tissues. Reactivity testing at Antibodies.com has confirmed binding to the IMPA2 target in human, mouse, and rat samples, so a single lot covers comparative work between rodent disease models and human cell-line or primary-tissue material.

Each vial ships at 100 µl, a size suited to extended panel experiments rather than one-shot applications. For Western blot, the antibody recognizes the endogenous protein in whole-cell lysates; for immunofluorescence, it can be applied to paraformaldehyde-fixed cells or tissue sections to localize IMPA2 within subcellular compartments. Users should aliquot the antibody on arrival and keep it frozen to avoid repeated freeze-thaw cycles, since polyclonal reagents lose titer with each round of thawing and refreezing.

Rabbit host and polyclonal clonality make this reagent a flexible building block in double-labeling designs with mouse monoclonals raised against a different epitope, and the unconjugated format preserves freedom to choose HRP, fluorophore, or biotin conjugates downstream.